Science/Technology

French dairy giant Danone leads $3.5m investment into Israeli cultured milk startup

French dairy giant Danone leads $3.5m investment into Israeli cultured milk startup

4 April, 2023

Strategic investment by company’s venture arm includes potential collaboration on cultured breast milk products; other investors include Steakholder Foods and Coca-Cola Israel

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French dairy giant Danone has entered into a strategic investment agreement with Israeli startup Wilk, which could lead to a collaboration with the food tech firm to develop cultured breast milk components for infant formula based on its cell technology.

Danone Manifesto Ventures (DMV), the corporate venture arm set up by the Paris-based food giant, will invest $2 million, leading a $3.5 million financing round announced by Wilk, in a filing to the Tel Aviv Stock Exchange on Monday.

Following the investment, the venture arm of the dairy company, which makes Activia yogurt, Aptamil infant formula and Evian water, will hold at least 2% of Wilk’s share capital.

 

Dr. Nurit Argov-Argaman of the Hebrew University of Jerusalem founded Wilk (as Biomilk) in 2018, and has since developed cell-based technology to produce cultured human breast and animal milk. Argov-Argaman took it public on the TASE in 2021 in a SPAC (special-purpose acquisition company) merger deal.

For the animal-derived cultured milk, Wilk isolates the milk-producing cells from cows’ udders and transfers them to a bioreactor, where they are exposed to materials patented by the firm to produce milk ingredients, but without needing a cow in the final milk-producing process.

 

The process is also applied to the lab production of human breast milk — complete with the fats and proteins that make up important parts of the nutritional value — using cells from breast reduction surgeries.

As part of the strategic agreement between Danone’s venture arm and Wilk, the parties will examine strategic cooperation for the development of breast milk substitutes that will include lab-grown breast milk components.

The agreement also stipulates that Danone and Wilk will examine possibilities for joint commercial cooperation and operations, which may include agreements for joint development and grants for projects in Europe and the US, Wilk said in a statement.

 

Wilk CEO Tomer Aizen said that DMV’s investment will help the firm continue in the development of its cultivated milk products.

Wilk is one of several Israeli food tech companies developing cultured, animal-free milk, each at a different development stage. Rehovot-based Remilk, for example, last year raised $120 million for cow-free milk, cheese and yogurt, and with production capabilities already off the ground. The developer of cultured milk and dairy has also announced plans to open the “world’s largest” facility for the production of cow-free milk in Denmark.

However, Wilk is one of few companies on the world stage in the cultured breast milk sector. Wilk’s offering could be a welcome alternative for those who prefer to give human milk, but face difficulties breastfeeding, for babies born prematurely, and for those who cannot consume commercial infant formula.

Wilk said it is not necessarily looking to replace infant formula, but to contribute to a product that is better nutritionally and with a cost comparable to formula.

As such, the Rehovot-based startup has been focusing on developing cell-cultured human milk fat for infant formula to replace vegetable fats currently contained in formula. The nutritional benefits of cultured human milk fat play a central role in maintaining an infant’s digestive system, as well as the development of its brain and nervous system, according to Wilk.

Other investors in the latest funding round, include Rehovot-based Steakholder Foods (formerly Meatech), an Israeli maker of cultivated meat products, which will purchase $450,000 in ordinary shares of Wilk at a 15% discount below their 45-day average closing price, giving the company a 2.5% stake in the Israeli startup. Steakholder Foods said it seeks synergies with Wilk, including strategic cooperation on its proprietary biology and printing technologies.

 

The Central Bottling Company, also known as Coca-Cola Israel, is also participating in the funding round. The owner of the Tara dairy cooperative, Israel’s second-largest milk processing company, invested $2 million in Wilk back in 2021 as part of an agreement to develop products based on the startup’s cultured milk technology.

As part of the financing round, Wilk will issue a total of 13.6 million ordinary shares in a private placement at a price of NIS 0.91 per share. The startup’s shares closed 10% lower on Monday at NIS 105.1 per share.

 

from: The Times of Israel

 

 

 

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Hebrew University Researchers Announce New Development: Selective Solar Energy Cells that Produce Green Electricity while Allowing Agricultural Cultivation of the Ground Below

Hebrew University Researchers Announce New Development: Selective Solar Energy Cells that Produce Green Electricity while Allowing Agricultural Cultivation of the Ground Below

19 December, 2022

 

This innovation will reduce the cost of energy per kWh in Israel by 75%; Covering half the greenhouses in Israel with these new cells will result in green electricity production exceeding Israel’s national target for 2050.

 

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A fruitful interdisciplinary collaboration between Prof. Haim Rabinowitch of the Hebrew University’s Robert H. Smith Faculty of Agriculture, Food and Environment, and Prof. Lioz Etgar of from the Institute of Chemistry at the Hebrew University yielded a prototype for a new solar cell whose efficiency has been technologically proven and whose performance stands to dramatically change the rules of the game regarding solar energy and agricultural production. This innovative solar cell is designed to fully cover agricultural areas (including greenhouses, orchards, and fields) and water bodies while simultaneously generating green electricity and agricultural  production, without interruption of natural habitats under the PV panels, without using up natural resources, and without harming the environment.

The new solar cells are based on perovskite crystals and are produced in a relatively straightforward process using cheap and available materials. A chemical substitution makes the solar cells transparent to the most efficient area of the light spectrum that drives photosynthesis, while a great part of the rest of the light energy is transformed into electricity. Prof. Lioz Etgar explains: “For years, it has been obvious that most light energy in agricultural greenhouses is wasted, as plants use only a fraction of the sunlight energy, while the rest is radiated back into the atmosphere. In greenhouses, it becomes heat energy, that growers need to get rid of during most months of the year.” He continues: “Our solution maximizes the production of solar electricity on agricultural land by up to 300%.” The new cells are expected to have much lower production costs than silicon-based photovoltaic cells, and will also significantly improve cultivation conditions in greenhouses by reducing heat, lowering greenhouse gas emissions and evapotranspiration, saving water, and protecting crops from weather damage, as well as offering partial protection from pests and disease.

All existing technologies for the generation of green power on agricultural lands deploy silicon-based photovoltaic cells, which are either fully opaque or only partially transparent to most of the light spectrum or laid in alternative arrays, thus resulting in lower efficiency of power generation and concomitantly reduced agricultural production. Prof. Haim Rabinowitch: “This new development, which can be installed over any agricultural lands and any bodies of water, will make it possible to fully replace the roofs of most agricultural greenhouses, reduce heat levels and evapotranspiration in orchards and fields, and impairment of many fresh-water and coastal marine ecosystems on which rafts or islands of solar cells are installed.”

Calculations based on current data indicate that the use of these new cells will reduce the price of energy per kWh in Israel by 75%, which will lower agricultural costs and increase agricultural income and profitability. This is nothing less than a revolution. Israel has a total of around 90,000 dunams (9,000 hectares) of greenhouses. Covering the greenhouses roofs of half of these with the new solar cells will provide a quantity of green electricity that enable Israel to exceed its 2050 national targets for green electricity production and carbon emission reduction. To give a greater idea of the economic potential of this development, the Mediterranean basin alone holds around 2 million dunams (200,000 hectares) of greenhouses.

A study published in 2018 in Global Food Security showed that the value of vegetable cultivation constitutes around 30% of the overall value of all crops combined, measured at around $1.85 billion. The process of photosynthesis with which all crops are grown uses about 10% of the total available light energy from the sun. Thus, it was only a matter of time before groundbreaking creative research would come up with a far more efficient solution for the combined production of electricity and agricultural produce, utilizing the remaining 90% of solar energy that is not used in photosynthesis.

The idea developed by Prof. Rabinowitch and Prof. Etgar, and their research program, were assessed by the Israel Innovation Authority, which provided a generous research grant. The proven results of this research were promoted by the Hebrew University’s technology-transfer Yissum and formed the basis for partnership with the Red Solar Flower initiative, led by Dr. Shai Danziger and Ilan Sharon. The successful research project to develop the solar cells, along with the Yissum-Red Solar Flower partnership, were recently recognized with the award of first place in the Energy Tech Challenge, led by the Digital SolarEdge company, as part of the Climate Solutions Prize organized by Start-Up Nation Central.

 

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The Philip Morris tobacco company spent NIS 3 million on advertising to increase its profits and drive addiction to smoking in the Haredi public

The Philip Morris tobacco company spent NIS 3 million on advertising to increase its profits and drive addiction to smoking in the Haredi public

30 November, 2022

A Hebrew University research study finds that 87% of cigarette advertisements targeting specific population groups were aimed at Haredi society, exploiting loopholes in the Prohibition of Advertising and Restriction of Marketing of Tobacco and Smoking Products Law.

A new research study, conducted by doctoral student Amal Khayat and led by Dr. Yael Bar-Zeev and researchers at the Hebrew University’s Braun School of Public Health and Community Medicine, shows that one of the world’s largest tobacco companies exploited loopholes in the law against advertising smoking products in Israel, and specifically targeted the Haredi population in Israel. The study findings, which were recently published in the academic journal Tobacco Control, reveal a series of advertising strategies that focused on the population group with the lowest rates of smoking in Israel.

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A new research study, conducted by doctoral student Amal Khayat and led by Dr. Yael Bar-Zeev and researchers at the Hebrew University’s Braun School of Public Health and Community Medicine, shows that one of the world’s largest tobacco companies exploited loopholes in the law against advertising smoking products in Israel, and specifically targeted the Haredi population in Israel. The study findings, which were recently published in the academic journal Tobacco Control, reveal a series of advertising strategies that focused on the population group with the lowest rates of smoking in Israel.

Analyzing the marketing data of Philip Morris International, the researchers examined the differences in advertising expenditure over a four-year period between advertising focused on different major population groups in Israel—the general population, the Haredi public, Arab speakers, and Russian speakers. “We conducted a comparison among the advertising expenditures for all Philip Morris cigarette brands and the IQOS brand (a heated tobacco stick that entered the local market in December 2016), in light of regulatory changes that restricted the advertising of tobacco products,” explains Khayat.

While the restriction on advertising tobacco products led to a significant reduction in the company’s marketing expenditures, the study shows that the company exploited legal loopholes in order to subvert the law’s goals and increase its own profits as much as possible. “Even after the law came into effect, the company continued to spend almost NIS 3 million on advertising, with a focus on the printed press,” explains Dr. Bar-Zeev. “While the law restricted print advertising to one advert in each newspaper, 40% of the IQOS adverts placed were giant, two-page adverts, which effectively doubled the product’s advertising space, while still being considered a single advert as allowed by the letter of the law.”

Another strategy used by Philip Morris was adding a QR code to the advert, which readers could scan and then view additional content, beyond that contained in the advert permitted in the newspaper. Furthermore, the adverts featured people smoking IQOS devices in closed public spaces, despite the fact that the law forbids

 

the use of any tobacco products in such areas. According to the researchers, adverts like this give the impression that such behavior is legally permitted, and exploits the innocence of the majority of consumers, who are not aware of these distinctions.

The study further finds that before the law came into effect, Philip Morris significantly increased its advertising to all the population groups examined, with a particular focus on the Haredi population, which had the lowest rates of smoking in Israel. “Our data shows that since the introduction of the IQOS e-cigarettes, 216 targeted adverts were published, of which 55% were for the Haredi public, 6% for the Arab public, and the rest for the Russian-speaking public,” says Dr. Bar-Zeev. Similarly, for regular cigarette brands, 87% of advertisements were targeted at the Haredi population—a surprising finding given the company’s repeated claims that it is only interested in marketing its products to existing smokers. Dr. Bar-Zeev adds: “We expected that the company would focus on populations with the highest rates of smoking in Israel—men in the Arab sector—and not on the population which has hardly any smokers.”

In the wake of the study findings, the previous Knesset assembly decided to cancel the exception for advertising in the printed press, but deferred implementation of this step for seven years. In discussions, a series of additional restrictions were decided upon for this interim period, including prohibitions on the use of coupons, on the use of QR codes, and on featuring cigarette packs which do not carry the mandatory plain packaging in adverts in the printed press. However, Dr. Bar-Zeev concludes that this is merely “a drop in the ocean,” as the study has proved that the tobacco companies bypass such restrictions, and find creative ways to continue marketing their products and getting a new generation of smokers addicted to them. The researchers argue that only a full and immediate ban on all forms of advertising, combined with strict enforcement of the law, can stop this happening.

 

The academic articles presenting the study findings are available here:

http://dx.doi.org/10.1136/tc-2022-057585

http://dx.doi.org/10.1136/tc-2022-057671

 

 

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Ancient DNA from Medieval Germany Tells Origin Story of Ashkenazi Jews

Ancient DNA from Medieval Germany Tells Origin Story of Ashkenazi Jews

30 November, 2022

DNA Analysis of 14th-Century German Jews, Led by Researchers at Hebrew University and Harvard, Shows Jewish Community was More Genetically Diverse than Modern Day Ashkenazim.

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Excavating ancient DNA from teeth, an international group of scientists peered into the lives of a once thriving medieval Ashkenazi Jewish community in Erfurt, Germany. The findings, shared today in the Journal Cell, show that the Erfurt Jewish community was more genetically diverse than modern day Ashkenazi Jews.

About half of Jews today are identified as Ashkenazi, meaning that they originate from Jews living in Central or Eastern Europe. The term was initially used to define a distinct cultural group of Jews who settled in the 10th century in Germany's Rhineland. Despite much speculation, many gaps exist in our understanding of their origins and demographic upheavals during the second millennium.

“Today, if you compare Ashkenazi Jews from the United States and Israel, they’re very similar genetically, almost like the same population regardless of where they live,” shared geneticist and co-author Professor Shai Carmi of the Hebrew University of Jerusalem (HU). But unlike today’s genetic uniformity, it turns out that the community was more diverse 600 years ago.

Digging into the ancient DNA of 33 Ashkenazi Jews from medieval Erfurt, the team discovered that the community can be categorized into what seems like two groups. One relates more to individuals from Middle Eastern populations and the other to European populations, possibly including migrants to Erfurt from the East. The findings suggest that there were at least two genetically distinct groups in medieval Erfurt. However, that genetic variability no longer exists in modern Ashkenazi Jews.

The Erfurt medieval Jewish community existed between the 11th and 15th centuries, with a short gap following a 1349 massacre. At times, it was a thriving community and one of the largest in Germany. Following the expulsion of all Jews in 1454, the city built a granary on top of the Jewish cemetery. In 2013, when the granary stood empty, the city permitted its conversion into a parking lot. This required additional construction and an archaeological rescue excavation.

“Our goal was to fill the gaps in our understanding of Ashkenazi Jewish early history through ancient DNA data,” explained Carmi. While ancient DNA data is a powerful tool to infer historical demographics, ancient Jewish DNA data is hard to come by, as Jewish law prohibits the disturbance of the dead in most circumstances. With the approval of the local Jewish community in Germany, the research team collected detached teeth from remains found in a 14th-century Jewish cemetery in Erfurt that underwent a rescue excavation.

The researchers also discovered that the founder event, which makes all Ashkenazi Jews today descendants of a small population, happened before the 14th century. For example, teasing through mitochondrial DNA, genetic materials we inherit from our mothers, they discovered that a third of the sampled Erfurt individuals share one specific sequence. The findings indicate that the early Ashkenazi Jewish population was so small that a third of Erfurt individuals descended from a single woman through their maternal lines.

At least eight of the Erfurt individuals also carried disease-causing genetic mutations common in modern-day Ashkenazi Jews but rare in other populations—a hallmark of the Ashkenazi Jewish founder event.

“Jews in Europe were a religious minority that was socially segregated, and they experienced periodic persecution,” described co-author Harvard University. Although antisemitic violence virtually wiped-out Erfurt’s Jewish community in 1349, Jews returned five years later and flourished into one of the largest in Germany. “Our work gives us direct insight into the structure of this community.”

The team believes the current study helps to establish an ethical basis for studies of ancient Jewish DNA. Many questions remain unanswered, such as how medieval Ashkenazi Jewish communities became genetically differentiated, how early Ashkenazi Jews related to Sephardi Jews, and how modern Jews relate to ones from ancient Judea.

While this is the largest ancient Jewish DNA study so far, it is limited to one cemetery and one period of time. Nevertheless, it was able to detect previously unknown genetic subgroups in medieval Ashkenazi Jews. The researchers hope that their study will pave the way for future analyses of samples from other sites, including those from antiquity, to continue unraveling the complexities of Jewish history.

“This work also provides a template for how a co-analysis of modern and ancient DNA data can shed light on the past,” concluded Reich. “Studies like this hold great promise not only for understanding Jewish history, but also that of any population.”

The research team, of over 30 scientists, included HU’s Shamam Waldman, a doctoral student in Carmi's group, who performed most of the data analysis.

 

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Hebrew University and Meta AI Launch Joint AI PhD Program to Drive Cutting-Edge Research

26 October, 2022

This first of its kind partnership between Meta and an Israeli university marks a significant step to bring industry-leading Artificial Intelligence research from Hebrew University’s Rachel and Selim Benin School of Computer Science and Engineering to the AI marketplace. 

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Today, the Hebrew University of Jerusalem (HU)’s School of Engineering and Computer Science and Yissum, HU’s technology transfer company announced a new research partnership with Meta AI.

This partnership stems from Hebrew University's efforts to strengthen the ties between academia and the tech industry. Meta AI’s research advances the state-of-the-art in artificial intelligence through fundamental and applied research in open collaboration with the community. PhD students who are accepted into the program will have the opportunity to merge theory with real work experience, to gain a better understanding of emerging technologies and to develop new ones. 

The results of the research conducted as part of this strategic partnership will be published for the benefit of the scientific community and industry. Meta will assign the HU students mentors and scholarships to deepen their understanding in AI and machine learning. Further, these students will have access to Meta’s computational infrastructure and facilities.

Professor Sara Cohen, Dean of the Rachel and Selim Benin School of Computer Science and Engineering at the Hebrew University: “This partnership offers our students a unique opportunity to experience the world of research and development from two perspectives: a research perspective that enables experimentation, innovation, and breakthroughs, and an implementation perspective, which will give them an understanding of the real-world impact of their research. This one-of-a-kind collaboration will empower Hebrew U.’s PhD students to both study at one of Israel’s leading universities and to test their ideas in Meta’s industry-leading AI laboratory.”

Dr. Itzik Goldwaser, CEO of Yissum: “Meta’s choice to collaborate with the Hebrew University is proof of our institution’s scientific excellence and the commercial success that Yissum has achieved for its leading professors. The university’s curious and innovative researchers play a critical role in the marketplace, and we are proud to facilitate this collaboration with Meta to impact the scientific community.”

Professor Joelle Pineau, Managing Director of FAIR: “Exploratory research, open science, and cross-collaboration are foundational to our AI efforts. Many of our projects are done with researchers both in industry and academia as we believe this is the fastest way to make progress in research. Bringing our PhD program to Israel, in partnership with the Hebrew University, will further our collective impact as we together accelerate the world's progress toward more capable AI."

 

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