Why Paracetamol Works: New Discovery Ends Longstanding Mystery
A new study from Hebrew University reveals that paracetamol doesn’t just work in the brain—it also blocks pain at its source by acting on nerve endings in the body. The researchers found that its active metabolite, AM404, shuts down specific sodium channels in pain-sensing neurons, stopping pain signals before they reach the brain. This discovery not only reshapes our understanding of how one of the world’s most common painkillers works, but also opens the door to developing safer, more targeted pain treatments.