Hidden Pocket in Human Bitter Taste Receptor Discovered
“Tasting Upside-Down - An Unusual Sensing Mechanism was Found in Human Bitter Sensing” A new study revealed that some bitter molecules target their sensor through binding simultaneously at two distinct locations, one outside the cell, and the other inside it. This discovery is fascinating because bitter taste receptors are expressed in extra-oral tissues and the new study shows the potential of our cells to sense not only external but also internal signals, opening up new possibilities for drug design, including asthma and inflammation.